北京桑拿网 北京品茶网 喝茶约茶 北京夜生活论坛国产成人综合自拍_欧美日韩在线视频免费观看_国产高清精品在线_欧美夜夜操_男女在线观看_久久久涩

產(chǎn)品中心

Rad17 (phospho Ser645) rabbit pAb
一鍵復(fù)制產(chǎn)品信息
ES1425
規(guī)格： 價(jià)格：
50μL ￥1280.00
100μL ￥1980.00

Overview

Product name: Rad17 (phospho Ser645) rabbit pAb
Reactivity: Human;Mouse
Alternative Names: RAD17; R24L; Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from human RAD17 around the phosphorylation site of Ser645. AA range:621-670
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 77kD
GeneID: 5884
Human Swiss-Prot No: O75943
Cellular localization: Nucleus . Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h
關(guān)閉

在線咨詢(xún)

Online consultation

  • 在線咨詢(xún)
  • 技術(shù)支持

關(guān)注微信公眾號(hào)

微信掃一掃立即咨詢(xún)

微信掃一掃立即咨詢(xún)

關(guān)閉